WebPamrevlumab, a recombinant human antibody that binds to connective tissue growth factor (CTGF) has emerged as a potential therapy for IPF and has advanced to phase 3 … WebInhibiting CTGF with antisense oligonucleotides, small interfering RNA, or neutralizing antibodies has been reported to reduce fibrosis in experimental models of kidney disease (Lee et al., 2015). The results of a phase I trial of FG-3019, an anti-CTGF antibody, demonstrated that this agent reduced albuminuria in patients with diabetic nephropathy.
CTGF Rabbit pAb-Polyclonal Antibodies - ABclonal
WebJun 22, 2006 · FG-3019 is an investigational fully human monoclonal antibody against CTGF. In a phase 1 study of FG-3019 in patients with idiopathic pulmonary fibrosis, FG-3019 was found safe and well tolerated. Currently, FG-3019 is the subject of a phase 1b study in diabetic patients with incipient nephropathy. WebMoreover, molecules aimed at blocking CTGF were identified to play an important role in the prevention of ocular fibrosis related to the TGFβ/Smad axis. The group of Wang et al. demonstrated that subconjunctival injection of a CTGF antibody was able to maintain larger bleb areas and lower intraocular pressures in a rabbit model of GFS . great lakes prosthetics \\u0026 orthotics
Targeting TGFβ signal transduction for cancer therapy
WebJun 6, 2012 · The mechanism by which CTGF enables persistent fibrosis upon stimulation by TGFβ has never been elucidated, due at least in part to the very complex … WebMonoclonal Antibody for studying CTGF. Cited in 36 publications. Validated for Western Blotting, Immunofluorescence (Immunocytochemistry). Highly specific and rigorously validated in-house, CTGF (D8Z8U) Rabbit Monoclonal Antibody (CST #86641) is ready to ship. ... Antibody Dilution Buffer (1X PBS / 1% BSA / 0.3% Triton X-100): To prepare 10 … WebClinical Trials Information. Find NCI-Supported Clinical Trials; What Are Clinical Trials? Paying for Clinical Trials; Patient Safety; Deciding to Take Part in a Trial; Questions to … great lakes property \u0026 investments